Indiana Tech spokesman Brian Englehart said the bus was carrying 16 members of the Fort Wayne school's men and women's bowling teams and members of the coaching staff to a tournament in Smyrna, Tennessee.
State Police Cpl. Carey Huls said the bus swerved to the left while traveling in Interstate 65's southbound lanes before swerving to the right and overturning. The accident happened just north of Henryville, about 20 miles north of Louisville, Kentucky.
"We don't know the cause but the bus did drive off the left side of the roadway and crossed back over both lanes before going off the right side of the road. It went over the embankment and overturned, and then it rolled into some trees," Huls said.
Video showed the white bus on its side in a grassy area off the highway with debris strewn about.
Englehart said all of the bowling team members are undergraduate students and the school was notifying their parents about the crash. He said school officials did not immediately know the extent of the injuries and had not determined how many and which coaching staff were aboard the bus.
Huls said eight people who apparently suffered minor injuries were taken to the Scott County Hospital, and the most seriously hurt were taken to University of Louisville Hospital, and most of those were airlifted. Huls said it's unclear how many were people taken to the Louisville hospital.
Clark County coroner Terry Conway said there were no fatalities at the crash scene.
Huls said in addition to 16 members of the bowling team, the team's coach and his wife were passengers on thebus, along with the driver.
"There could have been more on board, but at this point everybody's scattered to different hospitals," Huls said.
A Clark County sheriff's office dispatcher said six medical helicopters were called to the scene. Ground ambulances also were there.
Indiana Gov. Mike Pence said in a statement that "our hearts go out to the Hoosiers impacted by this morning's buscrash." He urged "all Hoosiers to hold these men and women in their thoughts and prayers."
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