Well, the guys at Portland-based Ducati dealer MotoCorsa would beg to differ. They were heading out to ride some remote countryside in Southeastern Oregon, but instead of taking their Multistrada, which Ducati designed to handle mixed road surfaces, they looked at their new 1199 Panigale S and thought, 'Why not?' So they fitted a set of knobby Continental TKC80 off-road tires on a fresh set of rims, coaxed some extra travel and ground clearance out of the suspension, swapped out the exhaust and painted the whole thing matte green.
They called the result the TerraCorsa, and report that it handled the moderate off-roading with aplomb. See for yourself in the video below, and check out Ride Apart for more.